Riset: Multivitamin Naikkan Risiko Kanker

MeRoX · Apr 20, 2010

Dapet berita nih dari yahoo bro & sis... moga berguna

VIVAnews – Perempuan yang mengonsumsi multivitamin tiap hari berpotensi mengidap kanker payudara. Demikian menurut studi yang dilakukan lebih dari sepuluh tahun terhadap 35 ribu perempuan oleh tim peneliti Karolinska Institute, Swedia, yang dimuat dalam jurnal the American Journal of Clinical Nutrition.

Penemuan tersebut mengguncang industri kesehatan Australia yang terus mendesak agar konsumen multivitamin tidak panik. Dalam penelitian tersebut, para peneliti menemukan bahwa mereka yang secara rutin mengonsumsi pil multivitamin meningkatkan risiko tumbuh tumor hingga 19 persen.

Hasil penelitian ini, seperti dikutip dari laman news.com.au, Minggu 18 April 2010, sangat mengkhawatirkan dan memerlukan penyelidikan lebih lanjut. Banyak perempuan justru mengonsumsi multivitamin karena yakin suplemen tersebut bisa mencegah penyakit-penyakit kronis seperti kanker.

Secara biologis, pendapat tersebut dapat dijelaskan demikian. Mengonsumsi suplemen vitamin dan mineral secara signifikan meningkatkan kerapatan atau kepadatan jaringan payudara yang merupakan faktor risiko tinggi pemicu kanker payudara. Asam folat, yang sering terkandung dalam bentuk padat dalam multivitamin, juga mampu meningkatkan pertumbuhan tumor.

Penemuan para peneliti Swedia ini disambut para pakar kesehatan Australia dengan ketertarikan dan kewaspadaan. Kanker payudara merupakan kanker paling umum diidap perempuan di Australia. Lebih dari 12 ribu wanita di Australia mengidap tumor ganas yang menewaskan lebih dari 2.700 perempuan tiap tahun. Satu dari sembilan perempuan di “Negeri Kanguru” tersebut akan didiagnosa mengidap penyakit mematikan ini pada usia 85 tahun.

“Hasil dari studi prospektif ini mengungkapkan bahwa penggunaan multivitamin bisa meningkatkan risiko kanker payudara,” kata ketua tim peneliti, Susanna Larrson.

Multivitamin termasuk bisnis besar di Australia. Produsen terkemuka multivitamin, Blackmores, bahkan meraup laba sebesar A$30,6 juta sebelum pajak untuk tahun fiskal tahun lalu. Sejumlah ahli gizi dan diet telah menegaskan bahwa suplemen tidak diperlukan karena tubuh manusia lebih mudah menyerap nutrisi dari makanan dibanding dari suplemen.
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sumber: link

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bloody_hound47 · Apr 20, 2010

wow, yang bener neh ?? bisa kena tumor juga malah, wew buat cw doank apa cowo jg bisa kena neh ?

catur_dr · Apr 20, 2010

masak sih? sebenarnya vitamin itu dibutuhkan tubuh, bilan brlebihan akan dibuang lwt urine atau empedu...
bisa-bisa produk multivitamin turun deh omzetnya....

malih16 · Apr 20, 2010

mungkin karna proses kimia pembuatan multivitamin jaman sekarang kali ya... apa kalo multivitamin alami (sayur dan buah2an) bisa meningkatkan resiko kanker juga?

MeRoX · Apr 20, 2010

ada lagi source yang saya dapat dari wikipedia tentang asam folat, yang dalam riset diatas dapat menyebabkan kanker; dan sepertinya bukan cuman buat wanita, buat laki-laki juga mungkin.

Cancer

Folate deficiency decreases intracellular S-adenosylmethionine (SAM) which inhibits cytosine methylation in DNA, activates proto-oncogenes, induces malignant transformations, causes DNA precursor imbalances, misincorporates uracil into DNA, and promotes chromosome breakage; all of these mechanisms increase the risk of prostate cancer development.

The association between folate and cancer appears to be complex. Even though theoretically it has been suggested that folate may help prevent cancer actual trials have found that supplementation increases rates of cancer.

Diets great in folate are associated with decreased risk of colorectal cancer; some studies show an association which is stronger for folate from foods alone than for folate from foods and supplements, while other studies find that folate from supplements is more effective due to greater bioavailability. A 2007 randomized clinical trial found that folate supplements did not reduce the risk of colorectal adenomas, but do in fact increase the presence of advanced lesions and adenoma multiplicity. Colorectal cancer is the most studied type of cancer in relation to folate and one carbon metabolism and most research studies associate high folate intake with a reduced risk of prostate cancer. However folic acid supplement intake increased advanced colorectal cancer development by 67% in a 14 year European research study involving 520,000 men.

A 2006 prospective study of 81,922 Swedish adults found that diets great in folate from foods, but not from supplements, were associated with a reduced risk of pancreatic cancer.

Most epidemiologic studies suggest that diets high in folate are associated with decreased risk of breast cancer, but results are not uniformly consistent: one broad cancer screening trial reported a potential harmful effect of much folate intake on breast cancer risk, suggesting that routine folate supplementation should not be recommended as a breast cancer preventive, but a 2007 Swedish prospective study found that much folate intake was associated with a lower incidence of postmenopausal breast cancer. A 2008 study has shown no significant effect of folic acid on overall risk of total invasive cancer or breast cancer among women. Folate intake may not have any effect on the risk of breast cancer but may have an effect for women who consume at least 15 g/d of alcohol. Folate intake of more than 300 µg/d may reduce the risk of breast cancer in women who consume alcohol.

In men, folic acid supplementation appears to double the risk of prostate cancer. Recently a clinical trial showed that daily supplementation of 1 mg of folic acid increased the risk of prostate cancer while dietary and plasma folate levels among non vitamin users actually decreased the risk of prostate cancer. The reasons why high levels of folic acid may increase cancer is because of its role in nucleotide synthesis (proliferating neoplastic cells need this and folate receptors are increased in cancers). Folate's role in DNA methylation is important in prostate cancer. Unmetabolized folic acid is associated with a reduction in natural killer cell cytotoxicity which reduces the immune system's ability to defend against malignant cells. However, the study also showed that dietary baseline intake of folate may have inverse effects of prostate cancer.[/B]

Some investigations have proposed that good levels of folic acid may be related to lower risk of esophageal, stomach, and ovarian cancer, but benefices of folic acid against cancer may depend on when it is taken and on individual conditions. In addition folic acid may not be helpful, and could even be damaging, in people who already are suffering from cancer or from a precancerous condition. Conversely, it has been suggested that excess folate may promote tumor initiation. Folate has shown to play a dual role in cancer development; low folate intake protects against early carcinogenesis but high folate intake promotes advanced carcinogenesis. Therefore public health recommendations should be careful not to encourage too much folate intake.
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sumber: wikipedia

gregorio2504 · Apr 20, 2010

nice info gan..
ini memace karena biasanya terjadi pengendapan

S1lver_8ullet · Apr 21, 2010

bahaya buat anak kost-an nih
seringnya suplemen karena gizi ga teratur

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